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Serine proteases

serine protease

(Science: enzyme) One of a group of endoproteases from both animal and bacterial sources that share a common reaction mechanism based on formation of an acyl enzyme intermediate on a specific active serine residue. Serine proteases are all irreversibly inactivated by a series of organophosphorus esters, such as di isopropylfluorophosphate (dFP) and by naturally occurring inhibitors (serpins). This group includes enzymes active in digestion, blood clotting, immune reactios, and fertilization of the ovum.

Examples are trypsin, chymotrypsin and the bacterial enzyme subtilisin.


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Edman Degradation Problem

... sequence of a protein isolated in the lab. You have used two different proteases to cleave the protein. These are the fragments after cleavage (all ... Protease I: Only between asparagine and threonine Protease II: Between Serine and cysteine, serine and threonine, and asaparagine and cysteine? ...

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by pinkerpikachu
Sun Oct 16, 2011 7:35 pm
 
Forum: Molecular Biology
Topic: Edman Degradation Problem
Replies: 1
Views: 3918

The Fiber Disease

... pathogen in nosocomial pneumonia. P. aeruginosa secretes a number of proteases that contribute to its virulence. We hypothesized that P. aeruginosa ... by protease IV, and degradation was inhibited by the trypsin-like serine protease inhibitor Nalpha-p-tosyl-L-lysine-chloromethyl ketone (TLCK). ...

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by Nadas Moksha
Sat Sep 09, 2006 4:20 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5427664

The Fiber Disease

... kicked out of the derm clinics, too costly), is by this thing called Proteases. Interestingly enough, these folks with this new medial subspecialty ... as hydrolases........ There are currently six classes of proteases: Serine proteases Threonine proteases Cysteine proteases Aspartic acid proteases ...

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by Skytroll
Mon Sep 04, 2006 4:01 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5427664

Proteasis

I've never looked at the sequences for proteases, but might there be an accessibility problems for proteases as well? To clarify, might a serine protease not find serines on another protease, or another serine protease? It would be evolutionary ...

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by tranjo
Sun Jun 04, 2006 4:57 am
 
Forum: Molecular Biology
Topic: Proteasis
Replies: 8
Views: 4135

Transcription / translation rate, nucleases and degradation

... "shipped" to places, like the P-bodies during the cell cycle. Proteases are not specific for a particular protein, but are particular for amino acid sequences. Like Serine proteases. I think there are exceptions to everything I just wrote, but I hope ...

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by tranjo
Sat Jun 03, 2006 3:49 pm
 
Forum: Molecular Biology
Topic: Transcription / translation rate, nucleases and degradation
Replies: 1
Views: 1271


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