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Self antigen

Definition

noun, plural: self antigens

An exogenous antigen that is recognized as nonself by the immune system, which should be considered otherwise under normal conditions.


Supplement

Production of autoantigens occurs under normal conditions, especially when a cell becomes neoplastic that it has to be recognized and acted upon by the immune system. However, when the immune system continues to fail to recognize own constituent parts as self it can lead to an autoimmune disease.


Word origin: self + antigen.

Also called: autoantigen

See also: autoimmunity


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Purpose of the Appendix

... immunological role as e.g. tonsils. That means that they contain lymphatic tissue, where some immunological events take place; probably microbe antigen presentation by macrophages and such cells to T cells. This function is so small, however, that no noticeable effects are usually seen and humans ...

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by biohazard
Tue Sep 08, 2009 12:48 pm
 
Forum: General Discussion
Topic: Purpose of the Appendix
Replies: 3
Views: 81

b cells and active immunity

... lessons... But how this decision then is made I don't know. I'd guess that plasma cells producing Antibodies with extremly strong affinity to the antigen might be selected to be memory cells. Maybe through longterm binding to APCs and simultanous licencing through T helper cells?! But it's just ...

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by apolll
Sun Aug 23, 2009 8:55 pm
 
Forum: Cell Biology
Topic: b cells and active immunity
Replies: 2
Views: 172

b cells and active immunity

I have a question about developing active immunity. Upon recognizing some antigen, B cells are stimulated to divide into either plasma cells or memory cells. My question is how Memory cells are 'chosen' for the job. I understand that they're clones by process, ...

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by raneynickel
Sat Aug 08, 2009 12:53 am
 
Forum: Cell Biology
Topic: b cells and active immunity
Replies: 2
Views: 172

Research in plants producing human antibodies!!?

... out the gene that makes the antibody?...I know they are companies online that can produce a specific antibody from injecting a mammal with an antigen. I think I can get 20uL for a cost. I assume I derive the DNA sequence from this, thus allowing me to create the gene.....right?..through an ...

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by seamoro
Wed Jul 01, 2009 6:15 pm
 
Forum: Molecular Biology
Topic: Research in plants producing human antibodies!!?
Replies: 3
Views: 221

The Immune System - Recognition in innate immunity. How?

... immune system has many components (located on the cell surface or secreted into plasma, for example), but in general they target such pathogenic antigens/structures that are common to microbes but not present in the host body. This way the receptors that recognize these can be assembled straight ...

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by biohazard
Tue May 12, 2009 7:43 am
 
Forum: Cell Biology
Topic: The Immune System - Recognition in innate immunity. How?
Replies: 1
Views: 1357
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