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Selenocysteine

selenocysteine

(Science: amino acid) An unusual amino acid of proteins, the selenium analogue of cysteine, in which a selenium atom replaces sulphur. Involved in the catalytic mechanism of seleno enzymes such as formate dehydrogenase of e. Coli and mammalian glutathione peroxidase. May be co translationally coded by a special opal suppressor tRNAase that recognises certain UGA nonsense codons.


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Isoelectric points of selenocysteine and pyrrolysin

Hallo, I am looking for the isoelectric points of selenocysteine and pyrrolysin, but so far, I was unable to find them. All sources I have found so far state that the pIs for these two are "unknown" - but can this really be the case? They ...

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by 3of8
Sat Feb 27, 2010 12:00 am
 
Forum: Molecular Biology
Topic: Isoelectric points of selenocysteine and pyrrolysin
Replies: 0
Views: 843

minor/major Amino acids

... minor amino acids as amino acids that get incorporated into proteins as-is, like the 20 canonical amino acids. The two most well characterized are selenocysteine and pyrolysine, but I'm sure there are others. Of course, this is just my gut instinct, I don't know any books to pack this up

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by MrMistery
Sat Dec 19, 2009 1:19 am
 
Forum: Physiology
Topic: minor/major Amino acids
Replies: 5
Views: 4655

mechanism to make a 250 aa protein from a 300 bp ORF

I think it would be similar to the selenocysteine story, coded by a stop codon: http://en.wikipedia.org/wiki/Selenocysteine

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by canalon
Wed Nov 11, 2009 2:16 am
 
Forum: Molecular Biology
Topic: mechanism to make a 250 aa protein from a 300 bp ORF
Replies: 14
Views: 4701

mechanism to make a 250 aa protein from a 300 bp ORF

... ask about it in another part of the question, and i'm guessing the answer they want is something along the lines of "it's the same thing as selenocysteine only with telurium". My question concerns the extra amino acids - for a 300 bp ORF one would expect a 99 or 98 aa peptide. where ...

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by MrMistery
Wed Nov 11, 2009 1:00 am
 
Forum: Molecular Biology
Topic: mechanism to make a 250 aa protein from a 300 bp ORF
Replies: 14
Views: 4701

a question needing an answer

well if you only had 21 codons (what's your 21st codon by the way, selenocysteine?) and the rest up until 64 were stop codons, then you would have a lot of nonsense mutations. being degenerate makes a lot of mutations silent.

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by MrMistery
Sat Mar 07, 2009 6:33 pm
 
Forum: Molecular Biology
Topic: a question needing an answer
Replies: 1
Views: 1292
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