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Selectin

selectin

(Science: protein) group of cell adhesion molecules that bid to carbohydrates via a lectin like domain. The name is derived from select and lectin.

They are integral membrane glycoproteins with an N terminal, c type lectin domain, followed by an eGF like domain, a variable number of repeats of the short consensus sequence of complement regulatory proteins and a single transmembrane domain.

Three selectins have been identified and are distinguished by capital letters based on the source of the original identification i.e. E selectin, L selectin and p selectin.


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Immunohistochemistry HELP--paraffin vs frozen sections

... slide staining, and I'm having problems getting the staining to show correctly. So far, I've been staining lymph node tissue for CD62L (L-selectin) and CD3, both of which are supposed to be quite abundant on the surface of regular T cells in the lymph node (this is a control). First, I ...

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by wetheril
Fri Mar 30, 2007 8:48 pm
 
Forum: Molecular Biology
Topic: Immunohistochemistry HELP--paraffin vs frozen sections
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