Dictionary » S » Secretase

Secretase

secretase

(Science: enzyme) Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms

Registry number: EC 3.4.99.-

Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


Amyloid beta (A4) precursor protein degradation products

... plaques) and a variety of sizes ranging from APP intracellular domain (AICD). The traditional view is that the APP degradation by two ways. Α-secretase pathway: (1), also known as non-amyloid formation routes. Followed by the alpha, gamma secretase cutting, resulting in the exocytosis of APP ...

See entire post
by Anonymous
Tue Jun 12, 2012 3:11 am
 
Forum: General Discussion
Topic: Amyloid beta (A4) precursor protein degradation products
Replies: 1
Views: 5430


This page was last modified 21:16, 3 October 2005. This page has been accessed 858 times. 
What links here | Related changes | Permanent link