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Secretase

secretase

(Science: enzyme) Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms

Registry number: EC 3.4.99.-

Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase


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Amyloid beta (A4) precursor protein degradation products

... plaques) and a variety of sizes ranging from APP intracellular domain (AICD). The traditional view is that the APP degradation by two ways. Α-secretase pathway: (1), also known as non-amyloid formation routes. Followed by the alpha, gamma secretase cutting, resulting in the exocytosis of APP ...

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by Anonymous
Tue Jun 12, 2012 3:11 am
 
Forum: General Discussion
Topic: Amyloid beta (A4) precursor protein degradation products
Replies: 1
Views: 3926


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