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Sanarelli phenomenon

Sanarelli phenomenon --> generalised Shwartzman phenomenon

When both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread haemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunological basis.

Synonym: sanarelli phenomenon, sanarelli-Shwartzman phenomenon.


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