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Reduced penetrance

Definition

noun

A form of penetrance below 100%, in which not all individuals carrying a deleterious gene express the associated trait or condition.


Supplement

A disease is said to show incomplete penetrance when some individuals express the associated trait while others do not even though they carry the disease-causing gene. For instance, some people with a mutation in the BRCA1 or BRCA2 gene will develop cancer during their lifetime, other people will not.


‘’Synonym:’’ incomplete penetrance

Compare: complete penetrance


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Reduced penetrance vs. multifactorial?

Penetrance is used as a statistical tool to determine the risk of getting ill when you have ... well-known mutation. So, I don't think it's vital to distinguish if a disorder has reduced penetrance or multifactorial trait. Of course, this information would be helpful to ...

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by DRT23
Wed Apr 06, 2011 10:34 am
 
Forum: Genetics
Topic: Reduced penetrance vs. multifactorial?
Replies: 1
Views: 2540

Reduced penetrance vs. multifactorial?

... to distinguish between a disease caused by a single-gene trait with low penetrance and a multifactorial trait? Let's say you were presented with ... off point between describing something as a single gene disorder with reduced penetrance and a polygenic disorder? (i.e. is it still meaningful ...

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by Grumbot
Mon Apr 04, 2011 4:23 pm
 
Forum: Genetics
Topic: Reduced penetrance vs. multifactorial?
Replies: 1
Views: 2540


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