Recombinase

Definition

noun, plural: recombinases

A nuclease associated with DNA recombination events


Supplement

Recombinases are enzymes of genetic recombination. They are used to catalyze site-specific recombination events (i.e. DNA breakage, strand exchange between homologous segments, and rejoining of the DNA via DNA ligases)1 in order to manipulate the structure of genomes as well as to control gene expressions. They are also used in recombinational DNA repair.1 They are derived from bacteria and fungi. These enzymes are capable of recognizing and binding to specific sites of DNA. They, then, bring short pieces of DNA (about 30 to 40 nucleotides) and then recombine them for synapsis.2 There are two types of recombinases based on amino acid sequence homology and the mechanism involved: (1) tyrosine recombinase family and (2) serine recombinase family. The tyrosine recombinases include Cre recombinase, FLP recombinase, etc. The serine recombinases include gamma-delta resolvase, Tn3 resolvase and phiC31 integrase.3


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Related term(s):

Reference(s):
1 Nature.com. (2015). Recombinases. Retrieved from [1]
2 American Mathematical Society, Mathematical Association of America. (2002). Mathematical Reviews. University of Michigan. p.9151.
3 Proteopedia.org. (2014). Resolvase. Retrieved from [2]

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