cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behaviour of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.
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... genetically modified the worm C. elegans to make human proteins called receptors in these nerves: the modified worms detect and avoid human signalling ... which are ’sensors’ at the surface of cells. The team introduced the somatostatin receptor (Sstr2) and the chemokine receptor 5 (CCR5) in the ...
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