receptors on the plasma membrane of nonhepatic cells that specifically bind ldl. The receptors are localised in specialised regions called coated pits. Hypercholesteraemia is caused by an allelic genetic defect of three types: 1) receptors do not bind to ldl; 2) there is reduced binding of ldl; and 3) there is normal binding but no internalization of ldl. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl coA reductase is lacking.
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... asked to compare and contrast the endocytic pathway for internalizing LDL and the endocytic pathway that delievers transferrin-bound iron to cells. How can i do it? i know the two involve different enzymes and receptors. What are the other main differences? Thanks in advance!! XD
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