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Receptors interleukin-2

receptors, interleukin-2

receptors present on activated t- and b-cells as a complex consisting of a 55 kD peptide, which reacts with the anti-tac monoclonal antibody, and a 75 kD non-tac interleukin-2-binding peptide. The receptor is present in two forms, one with a very high affinity and the other with low affinity for il-2. The high-affinity form appears to mediate exclusively the growth-promoting response to il-2. The receptor is present in large numbers on resting hTLV-I leukaemia cells, but not on normal resting cells.


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Re: Cytokine - Receptor concepts

... that might help. There are usually more than one receptor for a type of interleukin on the cell surface, however some interleukins, when they are bound cause the cell to express more receptors of a particular type of interleukin, and so increasing the chance of binding ...

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by Nataly56
Thu Jul 14, 2011 7:47 am
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14908

Cytokine - Receptor concepts

... questions. Here i am asking about the binding of the cytokines to their receptors on the cell surface. I've faced with texts like for example interleukin-12 binds to its receptor on T cells and initiates a change in the cell performance. ...

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by Saham
Fri May 21, 2010 5:22 pm
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 14908


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