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Reading frame shift

Definition

noun

A type of gene mutation wherein the addition or deletion of (a number of) nucleotide(s) causes a shift in the reading frame of the codons in the mRNA, thus, may eventually lead to the alteration in the amino acid sequence at protein translation.


Supplement

Mutations involving the genes are of two major types:

Frameshift mutations may be beneficial, deleterious, or lethal. For example, induction of frameshift mutation has been used to make certain bacteria capable of producing nylonase, an enzyme that can degrade nylon.

Frameshift mutation has also been one of the possible causes of albinism. A shift in the reading frame can lead to formation of stop codon, hence, early terminating protein translation. An early termination of any of the enzymes necessary for the production of melanin can result in albinism.

Tay Sachs disease is an example of a disease caused by frameshift mutation. The disease is caused by various mutations, including frameshift mutations, on chromosome 15 in the HEXA gene that codes for the alpha-subunit of the lysosomal enzyme beta-N-acetylhexosaminidase A.


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nylonase refuted?

... of (a number of) nucleotide(s) causes a shift in the reading frame of the codons in the mRNA, thus, may eventually lead to the ...

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by bellyjelly
Tue Jul 12, 2011 7:51 am
 
Forum: Evolution
Topic: nylonase refuted?
Replies: 12
Views: 10107

Re: nylonase refuted?

... could help me understand this. From what I'm reading, the paper claims that gene duplication and frame-shift mutation are not sufficient to account for new genes. Nylonase ...

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by robsabba
Mon Dec 21, 2009 4:24 pm
 
Forum: Evolution
Topic: nylonase refuted?
Replies: 12
Views: 10107

nylonase refuted?

... could help me understand this. From what I'm reading, the paper claims that gene duplication and frame-shift mutation are not sufficient to account for new genes. Nylonase ...

See entire post
by adkinsjr
Sat Dec 19, 2009 10:43 am
 
Forum: Evolution
Topic: nylonase refuted?
Replies: 12
Views: 10107

Help needed with a few DNA questions. Please.

... 4. now, this is a little interesting. You just shift the reading frame by one, sou will read it as CCA|TAC|AAC|TTC|TCAC|A so, guess, ...

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by JackBean
Fri Nov 20, 2009 2:40 am
 
Forum: Cell Biology
Topic: Help needed with a few DNA questions. Please.
Replies: 1
Views: 1913

making proteins

... by a change in the base sequence,causing a reading frame shift,producing different amino acids.however in this case, no amino ...

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by chenwithasterisk
Tue Jan 02, 2007 3:37 am
 
Forum: Genetics
Topic: making proteins
Replies: 5
Views: 2306
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