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Prp

PrP

(Science: protein) PrPc is a normal protein anchored to the outer surface of neurons and, to a lesser extent, the surfaces of other cells, including lymphocytes. The prion thought to be responsible for scrapie and other spongiform encephalopathies is hypothesised to be a modified form of PrPc, PrPSc.


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Question about CJD

I would just like to confirm my understanding of CJD (creutzfeldt Jakob Disease) My notes say that the PrPc protein is converted by some unknown protein x into PrP* Would this protein x be the prion? Also, the effect of this conversion is that the PrP* will use a PrPsc protein ...

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by Brodo
Thu Mar 31, 2011 5:24 am
 
Forum: Genetics
Topic: Question about CJD
Replies: 3
Views: 1386

Thanks for catching up my mistakes!!

Thanks for catching up my mistakes!! But one question, then what is the difference between PrP and PrP* in the structure?

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by Tae Jun, Yoon
Sat Apr 14, 2007 9:45 am
 
Forum: Molecular Biology
Topic: Imagination about electrophoresis
Replies: 7
Views: 3593

Imagination about electrophoresis

First, prp and prp* have the same amino acid sequence, so protein electrophoresis, which is often done in denturing conditions is not the best tool to detect the presence of prp* in beef. In fact antibodies are better suited ...

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by canalon
Fri Apr 13, 2007 8:53 pm
 
Forum: Molecular Biology
Topic: Imagination about electrophoresis
Replies: 7
Views: 3593

The Fiber Disease

... of familial CJD H187R in a cell model. For an efficient experimental readout, green fluorescent protein (GFP)-tagged mutant prion protein (PrP187R-GFP) and wild-type PrP (PrPC-GFP) were expressed in human neuroblastoma cells. We report that unlike PrPC-GFP that is expressed on the cell ...

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by J Jill
Sun Dec 10, 2006 4:48 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5479026

prions

Skytroll, About your post on 9/11 re. prions and protease-resistant PrP isoform detected in urine of hamsters, cattle and humans suffering from transmissible spongiform encephalopathies: Are you familiar with the book called "Brain Trust, The Hidden Connection ...

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by nettimo
Tue Sep 12, 2006 11:29 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5479026
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