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Proteasome

proteasome

(Science: cell biology) proteolytic complexes that degrade cytosolic and nuclear proteins. Implicated in aTP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD).

Origin: Gr. Soma = body


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The Fiber Disease

... know you created the other line of genes. Nucelation and cloning. Even skin nerves can be controlled can't they? "New Products for Ubiquitin-Proteasome Research Analyze Ubiquitin pathways with new Upstate® antibodies, proteins, and inhibitors from Millipore. The newest addition to our extensive ...

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by Skytroll
Sat Nov 04, 2006 4:49 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 748681

The Fiber Disease

... warfighters, the other of molecular-level mechanisms of natural resistance. Military Operational Medicine (MOM) • Delineated the role of the proteasome in neuroprotection from hemorrhagic shock in rats. • Initiated studies exploring possible genetic basis for abnormal responses to exertional ...

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by Nadas Moksha
Sun Sep 10, 2006 3:50 am
 
Forum: Human Biology
Topic: The Fiber Disease
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APC

... the T cells do it? Is it through the positive selection of T cell during T cell maturation? In cytoplasm there is a giant protein complex known as proteasome that will cut viral protein into peptides. After some steps of reaction (if you need this in detail, I'll explain it later, this is a bit ...

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by Nite
Mon Mar 27, 2006 4:36 pm
 
Forum: Physiology
Topic: APC
Replies: 17
Views: 3980

APC

... bind nonspecifically to virus before it comes into nucleus to hijack infected-cell's DNA. In cytoplasm there is a giant protein complex known as proteasome that will cut viral protein into peptides. After some steps of reaction (if you need this in detail, I'll explain it later, this is a bit ...

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by Dr.Stein
Mon Feb 20, 2006 10:01 am
 
Forum: Physiology
Topic: APC
Replies: 17
Views: 3980

Re: mRNA

... the nucleotides are reused, but I have to be really specific! Any help would be awesome! :) i think the mRNA is ubiquitinated and degraded in the proteasome.

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by sdekivit
Tue Nov 29, 2005 9:00 pm
 
Forum: Molecular Biology
Topic: mRNA
Replies: 6
Views: 1382
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