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Proteasome

proteasome

(Science: cell biology) proteolytic complexes that degrade cytosolic and nuclear proteins. Implicated in aTP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD).

Origin: Gr. Soma = body


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What does "deficient trafficking" means

I was reading a paper on disease mechanism where misfolding of a particular protein leads to its degradation by ubiquitin proteasome pathway and deficient trafficking to the lysosome. What does deficient trafficking means and overall what does this sentence means?? Kindly help me in ...

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by KSJ
Wed Jul 02, 2014 3:10 am
 
Forum: Cell Biology
Topic: What does "deficient trafficking" means
Replies: 1
Views: 409

Amyloid beta (A4) precursor protein degradation products

... a variety of pathological effects of intracellular A beta in Alzheimer's disease in the pathological process, including through the inhibition of proteasome activity and the promotion of tau protein aggregation in the mitochondria progressive aggregation inhibition of the respiratory chain enzyme ...

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by Anonymous
Tue Jun 12, 2012 3:11 am
 
Forum: General Discussion
Topic: Amyloid beta (A4) precursor protein degradation products
Replies: 1
Views: 6463

Re:

... seed proteins, but I'm not sure about auxins. If you inhibit transcription, overall level of all proteins will be decreased, but if you inhibit proteasome - degradative system for proteins, the levels will increase. Thus I would say: high levels 1, (2?), 6 middle level 7 low levels 3, 4, 5 Totally ...

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by cookiemonster1
Fri Feb 10, 2012 10:08 pm
 
Forum: Botany Discussion
Topic: Plant development...Check my answers please?
Replies: 3
Views: 1559

Plant development...Check my answers please?

... seed proteins, but I'm not sure about auxins. If you inhibit transcription, overall level of all proteins will be decreased, but if you inhibit proteasome - degradative system for proteins, the levels will increase. Thus I would say: high levels 1, (2?), 6 middle level 7 low levels 3, 4, 5

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by JackBean
Mon Jan 30, 2012 2:30 pm
 
Forum: Botany Discussion
Topic: Plant development...Check my answers please?
Replies: 3
Views: 1559

Plant development...Check my answers please?

... w/o gibberellic acid in the presence of an inhibitor of transcription 6. incubation withgibberellic acid in the presence of an inhibitor of the proteasome 7. incubation w/o gibberellic acid in the presence of an inhibitor of the proteosome My Answer: I said that 1 and 2 would have a significant ...

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by jjkwest1
Fri Jan 27, 2012 9:30 pm
 
Forum: Botany Discussion
Topic: Plant development...Check my answers please?
Replies: 3
Views: 1559
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