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Prostaglandin e2

prostaglandin E2 --> dinoprostone

(Science: chemical) 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid. The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Pharmacological action: oxytocics.

Chemical name: Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-


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Cardiovascular disease (CVD)

... platelets stick to the roughened surface and release clotting factors called thromboxanes. In healthy arteries the amount of thromboxane and prostaglandin is balanced, but in damaged arteries the balance is upset because the endothelial cells lining the artery are damaged so blood clots form. ...

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by sharleenreyna
Wed Apr 20, 2011 9:48 am
 
Forum: General Discussion
Topic: Cardiovascular disease (CVD)
Replies: 5
Views: 9872

Immunoassay kit 15-deoxy-delta 12,14-Prostaglandin J2

Hello, does anyone have an experience in the Immunoassay kit 15-deoxy-delta 12,14-Prostaglandin J2? I want to use it for adipose tissue and I need it to homogenize but in which buffer. I try to do it in PBS but every samples was absolutly wrong (doublets completely ...

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by svmichaela
Wed Oct 20, 2010 11:50 am
 
Forum: Molecular Biology
Topic: Immunoassay kit 15-deoxy-delta 12,14-Prostaglandin J2
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COX-2 and PGE2

Hi All, From what I understand, cyclo-oxygenase-2 (COX-2) is the enzyme for catalyzing the biosynthesis of prostaglandin E2, and hence the expression of the two entities are closely related. However, is anyone familiar with instances of when COX-2 and PGE2 have reciprocal expression? ...

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by ezther
Thu Nov 26, 2009 7:32 pm
 
Forum: Cell Biology
Topic: COX-2 and PGE2
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Re: What kills (and what saves) a corpus luteum?

It looks like the time bomb is a positive feedback loop between oxytocin and prostaglandin F2 (PGF2), initiated in the preovulatory follicle. PGF2... * causes degeneration of the capillary network supplying the corpus luteum, and * stimulates endothelial cells ...

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by jasonfahy
Mon May 05, 2008 4:58 pm
 
Forum: Human Biology
Topic: What kills (and what saves) a corpus luteum?
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Painkillers

prostaglandin synthesis occurs locally, where the pain occurs. google for "paracrine hormone" to find out more. Aspirin inhibits the syntehsis everywhere cause it travels through the blood

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by MrMistery
Mon Mar 10, 2008 6:48 pm
 
Forum: Cell Biology
Topic: Painkillers
Replies: 5
Views: 3645
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