Progeria

There are some genetic conditions that can affect nuclear membrane shape, in particular the laminopathy that causes Hutchinson-Gilford progeria. See figure 1 in the following paper for some nuclear membrane images: Scaffidi P, Gordon L, Misteli T (2005) The cell nucleus and aging: Tantalizing ...

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... aging of a cell. I don't think you'll find a single switch that explains it all. An interesting topic in aging is the disease Hutchinson-Gilford progeria, which ties in with the Lamin A topic I mentioned above.

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... Epub 2006 Apr 27. Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6.

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... * Optic Atrophy * Osteogenesis Imperfecta * Peutz-Jeghers Syndrome * Phenylketonuria (PKU) * Polycystic Kidney Disease * Prader-Willi Syndrome * Progeria * Pseudoxanthoma Elasticum * Ptosis * Rentinitis Pigmentosa * Scheie Syndrome * Schizophrenia * Severe Combined Immunodeficiency (SCID) * Sickle ...

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... in oligogenic Bardet-Biedl syndrome. Nature. 2006 Jan 19;439(7074):326-30. Epub 2005 Dec 4 Another intriguing syndrome is Hutchinson-Gilford progeria. Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science. 2006 May 19;312(5776):1059-63. Epub 2006 Apr 27. Scaffidi ...

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