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Proenzyme

proenzyme

(Science: biochemistry) A precursor of an enzyme that does not have full (or any) function until an inhibitory sequence has been removed.

This usually requires [[hydrolysis or limited {proteolysis]] of an inhibiting fragment that masks an active grouping) to render it active.

Examples include pepsinogen, trypsinogen, profibrolysin.

Synonym: zymogen.


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Zymography Question

... 45 Kda. By auto proteolytic cleavage the enzyme is activated during the incubation with developing buffer. Refered wikipedia "A zymogen (or proenzyme) is an inactive enzyme precursor. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing ...

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by karthik38
Thu Oct 04, 2007 10:20 am
 
Forum: Bioinformatics
Topic: Zymography Question
Replies: 1
Views: 4140

Zymography Question

... of the gel where there was enzyme activity during the incubation. A zymogen is simply the "inactive" precursor of an enzyme, or the proenzyme; for example, chymostrypsinogen is the proenzyme of chymotrypsin; chymotrypsinogen is activated by proteolysis to yield the active enzyme. ...

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by blcr11
Mon Apr 09, 2007 9:47 am
 
Forum: Cell Biology
Topic: Zymography Question
Replies: 1
Views: 1693

Denaturated proteine----> amino acid??

I don't think that HCl denaturates our protein. It is needed to activate such proenzyme, it also creates an acidic environment thus enzymes can work properly, also it functions for a desinfectant. The binding and dropping Hb molecules from HbO2 is not a denaturation ...

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by Dr.Stein
Wed Aug 03, 2005 2:16 am
 
Forum: Molecular Biology
Topic: Denaturated proteine----> amino acid??
Replies: 19
Views: 9307


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