Factor V

(Redirected from Proaccelerin)

Definition

noun

A blood coagulation factor that accelerates the conversion of prothrombin into thrombin in blood coagulation by forming a complex with activated coagulation factor X, phospholipid, and calcium ion


Supplement

Coagulation, the process of clot formation, involves platelet and blood clotting factors. In humans, the coagulation mechanism is comprised of two processes, i.e. the primary hemostasis and the secondary hemostasis. The latter entails two pathways: (1) intrinsic pathway (contact activation pathway) and (2) extrinsic pathway (tissue factor pathway). Both pathways lead to the formation of fibrin.

Factor V is heat- and storage-labile plasma glycoprotein that accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex (prothrombinase complex) with factor Xa, phospholipid, and calcium. Thus, factor V functions as a cofactor of factor X in blood coagulation.

Factor V is synthesized from the liver and the platelets. The gene coding for factor V is located on the 1st chromosome, i.e. 1q23. It is involved in both extrinsic and intrinsic pathways. Its activator is thrombin.

Deficiency of factor V leads to Owren's disease.


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