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Prion

prion

Origin: proteinaceous infectious particle

(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system.

The word, for proteinaceous infectious agent, was coined in 1982 by neurologist stanley Prusiner as part of a hypothesis regarding ailments bearing aetiologic resemblance to those caused by slow viruses (for instance, kuru). The hypothesis has been borne out by investigation. Prions are now believed responsible for several transmissible neurodegenerative diseases such as creutzfeldt-jakob disease (CJD), the human form of mad cow disease.

prions are infectious proteinaceous particles that lack nucleic acid. Prions are said to be in the border zone between nonliving and living things because they have no need to metabolize or the capacity to reproduce but they are capable of replication within the body of a human or of some mammals.

prions can gain entry into the body mainly by ingestion, e.g. of contaminated human Growth Hormone or of contaminated blood or blood products. Prions may also arise from a mutation in the gene that encodes the protein. They not only fold into unusual shapes but also seem to have the ability to cause other (normal) proteins to alter their shape as well.

Since in general the disease would show symptoms only after more than 30 years the prions have already accumulated and attacked nerve cells or brain tissues, leaving spongelike holes. Prion diseases have both infectious and hereditary components. The gene that codes for prions can mutate and be passed on to the next generation. Most of the diseases also can be acquired directly by infection, but unlike other infectious agents, prions provoke no immune response.


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A theoretical question - Genetic manipulation

... not practicability or current, solid proof. So here are the questions. 1. Is it theoretically possible, to actually 'create' a virus, bacteria, prion or other contagious, harmful organism, or only theoretically possible to alter the genetic make up of an already existing one? Whether it is possible ...

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by Maitreya
Sat Dec 07, 2013 6:41 pm
 
Forum: Microbiology
Topic: A theoretical question - Genetic manipulation
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Views: 4453

Living or not? (viruses,viroids and prions).

... that living organism is the one with protein or nucleic acid or both and imposes its own form and function into another, i would like to say that prions,viroids and viruses ARE LIVING as a prion changes a normal protein to function like itself, a viroid corrupts the normal RNA or DNA TO function ...

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by Sumanth001
Sun Jun 30, 2013 3:30 am
 
Forum: Microbiology
Topic: Living or not? (viruses,viroids and prions).
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Can prions change the shape of gelatin into a prion? Why or

To my knowledge, they can change only other prion protein, thus unless there is some prion protein in gelatin (which I doubt), it should not be a threat.

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by JackBean
Tue Sep 18, 2012 8:55 am
 
Forum: Human Biology
Topic: Can prions change the shape of gelatin into a prion? Why or
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Views: 1734

Can prions change the shape of gelatin into a prion? Why or

Prions are infectious proteins (misfolded proteins) found in animals. It caused by ingestion of contaminated meat. Basically, ground up bones/waste meat were used as protein supplement for livestock (dead cattle ingesting alive cattle), it allowed prions to move freely thus starting a disease such a...

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by hiyasminguyyoche
Mon Sep 17, 2012 9:45 am
 
Forum: Human Biology
Topic: Can prions change the shape of gelatin into a prion? Why or
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Fill in the Blanks??

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by biology1290
Mon Jan 23, 2012 3:29 am
 
Forum: General Discussion
Topic: Fill in the Blanks??
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