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Dictionary » P » Principle PrinciplePrinciple 1. Beginning; commencement. Doubting sad end of principle unsound. (Spenser) 2. A source, or origin; that from which anything proceeds; fundamental substance or energy; primordial substance; ultimate element, or cause. The soul of man is an active principle. (Tillotson) 3. An original faculty or endowment. Nature in your principles hath set [benignity] (Chaucer) Those active principles whose direct and ultimate object is the communication either of enjoyment or suffering. (Stewart) 4. A fundamental truth; a comprehensive law or doctrine, from which others are derived, or on which others are founded; a general truth; an elementary proposition; a maxim; an axiom; a postulate. Therefore, leaving the principles of the doctrine of christ, let us go on unto perfection. (Heb. Vi. 1) A good principle, not rightly understood, may prove as hurtful as a bad. (milton) 5. A settled rule of action; a governing law of conduct; an opinion or belief which exercises a directing influence on the life and behavior; a rule (usually, a right rule) of conduct consistently directing one's actions; as, a person of no principle. All kinds of dishonesty destroy our pretenses to an honest principle of mind. (law) 6. (Science: chemistry) Any original inherent constituent which characterises a substance, or gives it its essential properties, and which can usually be separated by analysis; applied especially to drugs]], plant extracts, etc. Cathartine is the bitter, purgative principle of senna. (Gregory) bitter principle, principle of contradiction, etc. See bitter, Contradiction, etc. Origin: f. Principe, L. Principium beginning, foundation, fr. Princeps, -cipis. See prince. ![]()
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Results from our forummutation-selection balance... it. In this case, p, the gene frequency of the lethal allele in the population, is equal to μ, the mutation rate (p = μ). We can use the same principles to predict the relationship between mutation and selection against recessive alleles. The Hardy-Weinberg principle showed that most copies ...
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Re: Gene targetingYes. Delivery efficiency to cells in adult tissue will not be 100%. There are likely to be regulatory barriers (legal restrictions). But, in principle it is possible.
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Re: question for evolutionary biologist.... On a general point as to whether this is a completely new genome. The answer is no, as this is just a first stage in that process. This proof of principle or concept was to determine whether it was possible to create a genome and insert it into a cell. The best way was to construct a genome that ...
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EC50 depending on cell number?... changes, etc.etc. or any other cell culture effects that might arise due to cell layers growing over each other or senescence etc. Just from the principle. Say I have compound X that I use in a 96-well format and in each well I have 1000 cells. I find out that I I have a receptor activation EC50 ...
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Re:... 1 you have neurotransmitters that induce the initial opening of channels, and as it builds up to the threshold number 2 is based on the physics principle and that a current travels faster with large diameter, there should be a math equation in your physiology book that deals with current and ...
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