Dictionary > Pribnow box

Pribnow box

Pribnow box –>
promoter
(Science: molecular biology) A region of dNA to which rNA polymerase binds before initiating the transcription of DNA into rNA.
The nucleotide at which transcription starts is designated -1 and nucleotides are numbered from this with negative numbers indicating upstream nucleotides and positive downstream nucleotides.
most bacterial promoters contain two consensus sequences that seem to be essential for the binding of the polymerase. The first, the pribnow box, is at about 10 and has the consensus sequence 5′ TATAAT 3′. The second, the 35 sequence, is centred about 35 and has the consensus sequence 5′ TTGACA 3′.
most factors that regulate gene transcription do so by binding at or near the promoter and affecting the initiation of transcription. Much less is known about eukaryote promoters, each of the three rNA polymerases has a different promoter.
rNA polymerase I recognises a single promoter for the precursor of rRNA.
rNA polymerase II, that transcribes all genes coding for polypeptides, recognises many thousands of promoters. most have the Goldberg Hogness or tATA box that is centred around position 25 and has the consensus sequence 5′ TATAAAA 3′. Several promoters have a cAAT box around 90 with the consensus sequence 5′ GGCCAATCT 3′. There is increasing evidence that all promoters for housekeeping genes contain multiple copies of a gC rich element that includes the sequence 5′ GGGC
731
GG 3′. Transcription by polymerase II is also affected by more distant elements known as enhancers.
rNA polymerase III synthesises 5s ribosomal RNA, all tRNAs and a number of small rNAs. The promoter for RNA polymerase III is located within the gene either as a single sequence, as in the 5s RNA gene or as two blocks, as in all tRNA genes.


You will also like...

Hominid
The Hominids

The hominid family diversified from the apes around 6 to 8 million years ago. Since then, the evolutionary path has prov..

Kidneys
Kidneys and Regulation of Water and Inorganic Ions

The kidneys are responsible for the regulation of water and inorganic ions. Read this tutorial to learn about the differ..

Ecosystem Succession
Ecosystem Succession

If the balance of nature is left untouched, landscapes can change dramatically over time. A previous ecosystem is supers..

Wart-like leaf galls on grape leaves
Plant Cell Defense

Plants protect themselves by releasing hydrogen peroxide to fight against fungal invasion. Another way is by secreting c..

IQ, Creativity and Learning
IQ, Creativity and Learning

Human intelligence provided the means to utilize abstract ideas and implement reasoning. This tutorial takes a further l..

Golgi apparatus (3-D illustration)
Role of Golgi Apparatus & Endoplasmic Reticulum in Protein Synthesis

The endoplasmic reticulum and Golgi apparatus are the organelles involved in the translation step of protein synthesis a..

Related Articles...

No related articles found

See all Related Topics