Preload

... repeatedly what happens to the force of contraction? and what is the mechanism behind this event finally -what happens to muscle at the highest preload forces. I've had to do a bunch of questions on this and these are the 3 that i just can't answer. Hope someone can help

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... can prevent the heart working as hard... e.g. beta blockers (reduce b1 adrenoreceptor activation), nitric vasodilators (venous dilation, reduce preload), calcium receptor antagonists (e.g. verapamil reduced afterload)...etc. but cardiac glycosides like digoxin increase heart workload... doesn't ...

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asutoshsahu, Are you thinking of Frank-Starling Law? Preload + Contractility = Afterload Basically...the volume entering the heart in addition to the efficacy of contractions is going to determine your systemic perfusion dynamics.

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... and dopamine...your sympathetic and parasympathetic nervous systems play a role in BP too...as well as plasma and Na+ .....and even the heart...preload, contractility, stroke volume.... There are many factors involved with regulating BP....

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Starling's law says that the force of contraction increases when preload increases. But a sympathetic inpulses increases, also (nor)adrenalin is produced in the adrenal gland. And these will cause the increased contraction in the heart. This is because when ...

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