Curare is a toxic substance used in making poisonous arrowheads and as an adjunct in anesthesia. This substance is a muscle relaxant. Physiologically, it works by blocking the motor end plate transmission. It inhibits the nicotinic acetylcholine receptor at the neuromuscular junction. It relaxes the voluntary muscles but not the involuntary muscles. It can be lethal when administered at sufficient doses. Parenteral administration of curare can cause asphyxiation and death to the target. Rudolf Boehm categorized curare into three common varieties: (1) tube curare, (2) pot curare, and (3) gourd curare.1 Pot curare is originally packed in terra cotta pots. The alkaloid components in pot curare include protocurarine, protocurine, and protocuridine. However, protocurarine and protocurine are the toxic alkaloid components; protocuridine is not toxic. And between tube curare and pot curare, tube curare is commonly the more toxic relative to their LD50 values.
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... movie star to the Amazon jungle promoting her/his newest action movie. While canoeing along with your dream date, you were shot in the leg with a curare-painted dart by a local native. Curare is a toxic plant alkaloid that binds tightly to acetylcholine receptors in skeletal muscle, blocking the ...
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It all depends on what is causing the paralysis, and what part of the body is affected. Some chemical causes include drugs based on curare, (the substance used on arrow tips in fights between cowboys and indians). This causes paralysis of the muscles needed for respiration. if artificial ...
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