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Polyprotein

polyprotein

(Science: protein) protein that, after synthesis, is cleaved to produce several functionally distinct polypeptides. Some viruses produce such proteins and some polypeptide hormones seem to be cleaved from a single precursor polyprotein (pro opimelanocortin, for example).


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Virus DNA/RNA Questions

To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them. if you mean RT = reverse transcriptase, ...

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by sdekivit
Sat Jul 28, 2007 9:36 pm
 
Forum: Microbiology
Topic: Virus DNA/RNA Questions
Replies: 9
Views: 6330

Virus DNA/RNA Questions

To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them.

See entire post
by ping
Sat Jul 28, 2007 6:45 am
 
Forum: Microbiology
Topic: Virus DNA/RNA Questions
Replies: 9
Views: 6330

HIV Reverse Transcriptase Enzyme

... incorporated HIV genome can be transcribed by the cell’s own RNA polymerase to make mRNAs that encode viral proteins—all of which are expressed as polyprotein precursors that need to be processed in some way in order to produce the final, active viral protein; the integrated viral genome also needs ...

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by blcr11
Thu Jul 19, 2007 10:18 pm
 
Forum: Molecular Biology
Topic: HIV Reverse Transcriptase Enzyme
Replies: 3
Views: 5322

HIV Reverse Transcriptase Enzyme

... isn't very much room to move, and there is no pool of dNTP, so even if it wanted to transcribe, it couldn't. The enzyme is made as an inactive polyprotein, gp160, that is packaged into an immature virion along with viral genomic RNA; the process of maturation cleaves gp160 into the mature capsid ...

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by blcr11
Tue Jul 17, 2007 5:31 pm
 
Forum: Molecular Biology
Topic: HIV Reverse Transcriptase Enzyme
Replies: 3
Views: 5322


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