Polyprotein

To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them. if you mean RT = reverse transcriptase, ...

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To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them.

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... incorporated HIV genome can be transcribed by the cell’s own RNA polymerase to make mRNAs that encode viral proteins—all of which are expressed as polyprotein precursors that need to be processed in some way in order to produce the final, active viral protein; the integrated viral genome also needs ...

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... isn't very much room to move, and there is no pool of dNTP, so even if it wanted to transcribe, it couldn't. The enzyme is made as an inactive polyprotein, gp160, that is packaged into an immature virion along with viral genomic RNA; the process of maturation cleaves gp160 into the mature capsid ...

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