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Dictionary » P » Polyadenylation

Polyadenylation

Definition

noun

The synthesis of a poly a tail at the end of an RNA molecule.


Supplement

The adding of a poly-A stretch at the end of mRNA helps protect the mRNA from degradation by exonucleases in the cytoplasm, and also helps in transcription termination, export of the mRNA from the nucleus, and translation.

The process is catalyzed by the enzyme, polyadenylate polymerase (PAP).


See also: adenine, mRNA.


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The Fiber Disease

... of the Autographa californica nuclear polyhedrosis virus (AcMNPV) followed by convenient restriction sites such as BamHI, Xba I and Asp718. The polyadenylation site of the simian virus 40 ("SV40") is used for efficient polyadenylation. For easy selection of recombinant virus, the plasmid ...

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Sat Oct 07, 2006 3:47 am
 
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DNA and tree vascular tissues

If a molecule of mRNA, prior to splicing or polyadenylation, has 15% A, 20% G, 30% U, and 35% C, what is the composition of the double-stranded DNA that it was transcribed from? a question from a past competition. and the answer is 22.5% T, 22.5% ...

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by mercuryy
Thu Jul 20, 2006 2:24 am
 
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Issues of EST in whole genome gene discovery

... post transcriptional control on a genomic level, which have been shown very successful, including studies in alternative splicing and alternative polyadenylation. Pioneer of these include Michael Zhang at CSHL, Chris Burge at MIT, and Chris Lee at UC. Please add.

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by cyberpostdoc
Mon Jun 27, 2005 4:24 am
 
Forum: Bioinformatics
Topic: Issues of EST in whole genome gene discovery
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