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Polyadenylation

Definition

noun

The synthesis of a poly a tail at the end of an RNA molecule.


Supplement

The adding of a poly-A stretch at the end of mRNA helps protect the mRNA from degradation by exonucleases in the cytoplasm, and also helps in transcription termination, export of the mRNA from the nucleus, and translation.

The process is catalyzed by the enzyme, polyadenylate polymerase (PAP).


See also: adenine, mRNA.


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Molecular bio questions

... that binds to a specific DNA sequence referred to as UAS and it promotes RNA synthesis: True or false I think the answer for this is true 2, Polyadenylation of mRNAs occurs in both prokaryotes and Eukaryotes and it has the same function True or false I think the answer for this is false

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by revision
Sun Nov 25, 2012 4:16 pm
 
Forum: Molecular Biology
Topic: Molecular bio questions
Replies: 2
Views: 1195

Re: Issues of EST in whole genome gene discovery

... post transcriptional control on a genomic level, which have been shown very successful, including studies in alternative splicing and alternative polyadenylation. Pioneer of these include Michael Zhang at CSHL, Chris Burge at MIT, and Chris Lee at UC. Please add.

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by merv
Sun Oct 02, 2011 7:46 pm
 
Forum: Bioinformatics
Topic: Issues of EST in whole genome gene discovery
Replies: 6
Views: 11423

prediction the coding sequence

... of which is known but can only be determined experimentally. Also, the cDNA gene sequence can undergo post-translational modifications, such as polyadenylation (which nearly always occurs but is different lengths in each cDNA even of the same gene, ie. a random length polyA tail) - and more ...

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by merv
Sun Oct 02, 2011 5:42 pm
 
Forum: Bioinformatics
Topic: prediction the coding sequence
Replies: 2
Views: 3714

RNA processing

We know that 5' capping and 3' polyadenylation are necessary for the mRNA in eucaryotes. These transformations do not happen in procaryotes. Which is the advantage in eucaryotes, excenp from the fact that the RNA is more protected from exonucleases?

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by biostud
Fri Jun 25, 2010 8:40 pm
 
Forum: Molecular Biology
Topic: RNA processing
Replies: 3
Views: 2800

Why polyadenylation?

Why is polyadenylation needed? I know it is necessary to protect the mRNA from nucleases, but i've read that it is also necessary during nuclear export and translation! Why? In what mechanisms does it participate?

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by biostud
Fri Jun 25, 2010 12:09 pm
 
Forum: Molecular Biology
Topic: Why polyadenylation?
Replies: 1
Views: 1004
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