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Poly a tail

Definition

noun

A long stretch of (about ten to 200 or more) adenine nucleotides added to the "tail" or 3' end of the pre-mRNA via the process called polyadenylation catalyzed by the enzyme, polyadenylate polymerase (PAP).


Supplement

In eukaryotic organisms, most messenger RNA molecules end with a poly-A stretch at their 3' ends. It is believed to protect the mRNA from degradation by exonucleases, and is essential for transcription termination, for export of the mRNA from the nucleus, and for translation.


See also: adenine, mRNA, polyadenylation.


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Pseudogene

... When I went back to its sequence on genome level, I do not find any poly A signal or Poly A tail. Also there is no signature of regulatory sequence upstream. Now I really wonder how on ...

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by sroy2
Fri Jul 22, 2011 1:03 pm
 
Forum: General Discussion
Topic: Pseudogene
Replies: 1
Views: 1890

Poly A >>> what the propose ?

... using certain protocol... and as i know it's better to add poly A tail, but the problem is my lecturer said that no need to add poly A tail.?! so now i got confuse ...

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by Nmr
Mon Nov 01, 2010 4:02 am
 
Forum: Molecular Biology
Topic: Poly A >>> what the propose ?
Replies: 5
Views: 2790

Poly A >>> what the propose ?

Hi guys i need ur help >>> what the propose of adding the poly A tail to the 5' terminus of the primer in PCR in Megaprimer method ? thanx

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by Nmr
Sun Oct 31, 2010 7:52 am
 
Forum: Molecular Biology
Topic: Poly A >>> what the propose ?
Replies: 5
Views: 2790

3' RACE no polyA tail???

... someone could help me: I want to do a 3' RACE on a sequence without a poly A tail- how can I do it?

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by Ammie
Thu Aug 06, 2009 10:51 am
 
Forum: Molecular Biology
Topic: 3' RACE no polyA tail???
Replies: 0
Views: 1277

why does taq add an "A"

is that something to do with a poly adenyl tail?

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by plasmodesmata11
Mon Mar 30, 2009 12:15 am
 
Forum: Molecular Biology
Topic: why does taq add an "A"
Replies: 4
Views: 1946
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