Dictionary » P » Point mutation

Point mutation

Definition

noun, plural: point mutations

A mutation in DNA or RNA molecule involving a change of only one nucleotide base.


Supplement

This type of mutation occurring in noncoding sequences often does not result in an altered amino acid sequence during translation. If a mutation in the promoter sequence of a gene occurs, the effect may be apparent since the expression of the gene may cause changes in the amino acid sequence, as well as the structure and function of the protein product.

Point mutations may be classified based on functionality:

Depending on the type of nitrogenous base involved, this type of mutation may be categorized as:

  • transition
  • transversion

Sometimes, point mutation also covers mutations caused by single nucleotide insertions or deletions (which are types of frameshift mutation).


Synonym:


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


Hyperadrenergic POTS

... in a kindred with hyperadrenergic POTS. These individuals have a single point mutation in the norepinephrine transporter (NET). The resultant inability to adequately clear ...

See entire post
by rmorrison
Wed Mar 19, 2014 5:38 pm
 
Forum: Human Biology
Topic: Hyperadrenergic POTS
Replies: 0
Views: 2611

Polymorphism and Mutation

Just about numbers. A mutation is a change to a single individual that may or may not be propagated. For example a single point mutation where a base is replaced or deleted from a strand of DNA. This may cause the individual some ...

See entire post
by Babybel56
Wed Mar 05, 2014 3:39 am
 
Forum: Molecular Biology
Topic: Polymorphism and Mutation
Replies: 2
Views: 1682

What makes dominant allele dominant?

... transcription to protein post-translational modifications. There can be mutation in the promotor changing significantly expression. If the binding ... will be impaired, there will be much less of protein made. Single point mutations can lead to differences in binding of miRNAs. On the protein ...

See entire post
by JackBean
Thu Feb 27, 2014 5:20 pm
 
Forum: Genetics
Topic: What makes dominant allele dominant?
Replies: 7
Views: 3933

SNV vs point mutation?

My professor seems to distinguish an SNP from an SNV from a point mutation. I seemed to think that an SNV and a point mutation were the same thing. So, what is the ...

See entire post
by jomjamson
Sat Jan 11, 2014 5:51 am
 
Forum: Molecular Biology
Topic: SNV vs point mutation?
Replies: 1
Views: 938

Re: Re:

... the more they accumulate the more opportunity there is for compensatory mutations to bring the basic fitness level back to a kind of running equilibrium ... of 1s and 2s. However, once the harmfulness accumulates to the point where some people are 11s or 12s, people start to die prematurely. ...

See entire post
by wildfunguy
Sat Oct 19, 2013 9:18 pm
 
Forum: Evolution
Topic: Beneficial mutations vs harmful
Replies: 12
Views: 7805
View all matching forum results

This page was last modified 01:34, 21 August 2010. This page has been accessed 62,512 times. 
What links here | Related changes | Permanent link