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Phospholipase c

phospholipase c

(Science: enzyme) An enzyme found in the alpha-toxin of clostridium welchii and other strains of clostridia and bacilli. It hydrolyzes glycerophosphatidates with the formation of 1,2-diacylglycerol and a phosphorylated nitrogenous base such as choline.

Chemical name: phosphatidylcholine cholinephosphohydrolase

Registry number: EC

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Re: molecular mechanism of inflammation

... or other stimuli. (The stimulus may even be an eicosanoid from a neighboring cell; the pathways are complex.) This triggers the release of a phospholipase at the cell membrane. The phospholipase travels to the nuclear membrane. There, the phospholipase catalyzes ester hydrolysis of phospholipid ...

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by jwalin
Mon Jan 18, 2010 9:56 am
Forum: Molecular Biology
Topic: molecular mechanism of inflammation
Replies: 9
Views: 7580

Re: lysosome

... "glycocalix" proteins but almost no references on a Pubmed search of lysosome + glycocalix. The lysosomes do indeed contain enzymes with phospholipase activity capable of damaging membranes, but these might not have access to the membranes without protein interactions. It seems that bits ...

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by hkornfeld
Thu Sep 17, 2009 10:19 pm
Forum: Cell Biology
Topic: lysosome
Replies: 11
Views: 17107

cAMP as second messenger in GPCR signal transduction

... we have. other examples include cGMP and Calcium ions. And no, GPCRs do relay the message solely through cAMP, they can, as I remember, activate phospholipase C and guanynyl cyclase as well.

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by MrMistery
Sun Feb 15, 2009 4:13 pm
Forum: Cell Biology
Topic: cAMP as second messenger in GPCR signal transduction
Replies: 3
Views: 5200

yes they are

... same gland as the venom gland of the gila monster. The venom produced by a varanid lizard also shares many toxins with the gila monster, such as phospholipase A2 toxins that block the aggregation of platelets, an essential aspect of being able to form a blood clot to stop bleeding. This works ...

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by venomdoc
Sat Oct 14, 2006 1:44 pm
Forum: Zoology Discussion
Topic: Are monitors venomous?
Replies: 9
Views: 7045

The Fiber Disease

... The Effects of Mastoparan on the Carrot Cell Plasma Membrane Polyphosphoinositide Phospholipase C http://www.plantphysiol.org/cgi/content/abstract/107/3/845 Mastoparan promotes exocytosis and increases intracellular cyclic AMP in ...

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by London
Tue Aug 29, 2006 7:40 pm
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6264642
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