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Phosphoinositide

phosphoinositide --> phosphatidylinositol

(Science: biochemistry) A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.

It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid.

The 4 phosphate (pIP) and 4, 5 bisphosphate derivatives pIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles).

signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: iP3). Both the diacyl glycerol and products act as second messengers.

Synonym: phosphoinositide.


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starch + glycogen

... messengers are not soluble in water. Use the back button to return to the main document. Glossary IRS-1 = insulin receptor substrate 1 PDK1 = 3-phosphoinositide dependent kinase 1 PI-3K = phosphatidylinositol 3 kinase PIP2 = phosphatidylinositol 4,5 bisphosphate PIP3 = phosphatidylinositol 3,4,5 ...

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by Dr.Stein
Mon Feb 06, 2006 9:04 am
 
Forum: Molecular Biology
Topic: starch + glycogen
Replies: 12
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