Dictionary » P » Phosphodiesterase



(Science: enzyme) An enzyme that cleaves phosphodiesters to give a phosphomonoester and a free hydroxyl group.

Examples include rNase, dNase, phospholipases C and D and the enzymes that convert cyclic nucleotides to the monoester forms. In casual usage the cAMP phosphodiesterase is usually meant.

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check out G-proteins and cAMP. a faulty phosphodiesterase might cause this kind of problem if you ask me..

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by MrMistery
Wed Nov 29, 2006 11:51 am
Forum: Cell Biology
Replies: 1
Views: 1089

The Fiber Disease

... corticotropin, lipotropin, vasopressin and specifically para-thyroid hormones and thyroid-stimulating hormones (TSH). When the amount of phosphodiesterase (which regulates the catabolism of cAMP) is increased, the active amounts of cAMP are reduced. Thus the effects of the above mentioned ...

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by Nadas Moksha
Mon Nov 27, 2006 1:25 am
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6245905


... a signal transduction pathway that uses cAMP and it is turned off, you have to "recycle" all that cAMP. this is done by an enzyme named phosphodiesterase, that turns cAMP into regular AMP. However, this would be a catastory if the cell would be using ADP-AMP. All that generated AMP would ...

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by MrMistery
Tue Feb 28, 2006 6:50 pm
Forum: Molecular Biology
Topic: ADD'P to ADP
Replies: 16
Views: 6094


... vasopressin receptors. 3. A novel class of GPCRs are the photoreceptors. This class is coupled to a G-protein termed transducin that activates a phosphodiesterase which leads to a decrease in the level of cGMP. The drop in cGMP then results in the closing of a Na+/Ca2+ channel leading to hyperpolarization ...

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by blindcat35
Sat Feb 04, 2006 6:31 am
Forum: Cell Biology
Topic: G-proteins
Replies: 4
Views: 7645

drugs and heart rate

... it via facilitated diffusion into the cytoplasm. Another level where caffeine function is that it inhibits the production of an enzyme named phosphodiesterase that results in cAMP not being recycled. About alcohol, all i know about influences on the cardiovascular system is that it determines ...

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by sdekivit
Tue Dec 13, 2005 8:21 pm
Forum: Cell Biology
Topic: drugs and heart rate
Replies: 5
Views: 3059
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