Dictionary » P » Phosphatidylinositol



(Science: biochemistry) A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide.

It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid.

The 4 phosphate (pIP) and 4, 5 bisphosphate derivatives pIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles).

signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: iP3). Both the diacyl glycerol and products act as second messengers.

Synonym: phosphoinositide.

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Cell signalling inhibitors

... for C. elegans (or generic) and tell me the enzyme or receptor that is inhibited? (Preferably for tyrosine kinase, G-protein, JAK/STAT and Phosphatidylinositol 3-kinase) Thanks :D

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by billyfisher100
Wed Jan 08, 2014 7:35 pm
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Re: Developmental Biology-I need help

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by jonmoulton
Fri Nov 07, 2008 7:03 pm
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The Fiber Disease

... | Racemization | N-O acyl shift N-terminus: Acetylation | Formylation | Myristoylation | Pyroglutamate C-terminus: Amidation | Glycosyl phosphatidylinositol (GPI) Lysine: Methylation | Acetylation | Hydroxylation | Ubiquitination | SUMOylation | Desmosine Cysteine: Disulfide bond | Prenylation ...

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by Skytroll
Wed Oct 04, 2006 2:39 am
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starch + glycogen

... the back button to return to the main document. Glossary IRS-1 = insulin receptor substrate 1 PDK1 = 3-phosphoinositide dependent kinase 1 PI-3K = phosphatidylinositol 3 kinase PIP2 = phosphatidylinositol 4,5 bisphosphate PIP3 = phosphatidylinositol 3,4,5 trisphosphate PKB =protein kinase B I think ...

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by Dr.Stein
Mon Feb 06, 2006 9:04 am
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