Peroxiredoxin 3

Definition

noun

A protein that is involved in the regulation of cellular proliferation, differentiation and antioxidant functions that has been localize in the mitochondrion.

Supplement

Peroxiredoxin 3 gene is mapped on chromosome 10q26.11 that contains 256 amino acids necessary for upholding normal function of mitochondrial mass and membrane potential in cells. It is well known to have an antioxidant properties implicated in the protection of cells from oxidative stress and functions as modulators of signal transduction, transcription and apoptosis.

Peroxiredoxin 3 expression is induced by oxidants in the cardiovascular system and is thought to play a role in the antioxidant defense system and homeostasis within mitochondria. It is a member of thioredoxin peroxidase that utilizes mitochondrial thioredoxin 2 as a source of reducing molecules to forage hydrogen peroxide.

Peroxiredoxin 3 is classified based on the position of cysteine residues implicated in catalysis in which some studies reveals that Peroxiredoxin 3 is significantly reduced in clear cell renal cell carcinoma (CCRCC) signifying that downregulation of this protein is required for HIF-1α dependent proliferation of CCRCC cells.

Gene name: PRDX3

Protein name: Thioredoxin-dependent peroxide reductase

Synonyms:

Antioxidant protein 1

AOP-1

MER5

SP-22

PRX3

See also:

Peroxiredoxin

Antioxidant protein

Thioredoxin peroxidase

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