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Peripheral membrane proteins

peripheral membrane protein

(Science: protein) membrane proteins that are bound to the surface of the membrane and not integrated into the hydrophobic region. Usually soluble and were originally thought to bind to integral proteins by ionic and other weak forces (and could therefore be removed by high ionic strength, for example). However, it is now clear that some peripheral membrane proteins are covalently linked to molecules that are part of the membrane bilayer (see acylated proteins and glypiation) and that there are others that fit the original definition but are perhps more appropriately considered proteins of the cytoskeleton (e.g. Band 4.1 and spectrin) or extracellular matrix (e.g. Fibronectin).


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Protein movment in cell membrane?

Integral proteins cannot move out of the bilayer, but they can diffuse to any side. Peripheral proteins are associated with one surface, but can scoot around on that surface. If you think of the cell membrane as the surface of a planet then these proteins can ...

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by jonmoulton
Tue Dec 13, 2011 5:06 pm
 
Forum: General Discussion
Topic: Protein movment in cell membrane?
Replies: 4
Views: 3313

Protein movment in cell membrane?

I was reading about the phospholipid bilayer/membranes and how it's fluid like in nature which is the reason why molecules such as proteins are able to move across it laterally. What ... which are firmly bound to the membrane and peripheral proteins which are not even embedded in ...

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by aic92
Tue Dec 13, 2011 4:42 pm
 
Forum: General Discussion
Topic: Protein movment in cell membrane?
Replies: 4
Views: 3313

Re: Specific Osmosis Question

... of water across a differentially permeable membrane due to concentration differences. That ... is composed of a phospholipid bilayer in which proteins are embedded (integral proteins) or also occur on the cytoplasmic side (peripheral proteins). And the hydrophobic tails that ...

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by chrisPbacon
Fri Sep 30, 2011 10:36 pm
 
Forum: Cell Biology
Topic: Specific Osmosis Question
Replies: 1
Views: 6321

Re: lysosome

Inside the lysosome membrane there is a thick "glycocalix" protective ... This "glycocalix" is made of special proteins called "Lysosome associated membrane proteins ... glycocalix is formed by lysosomal integral and peripheral membrane proteins, which are highly N-glycosylated ...

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by mlomize
Wed May 04, 2011 3:52 am
 
Forum: Cell Biology
Topic: lysosome
Replies: 11
Views: 14794

Re: proteins found in the cell membrane.

I was always taught there are 6 fundamental membrane proteins. 1. Carrier proteins (Facilitative, active, aquaporins etc) 2. Enzyme proteins (Integral and peripheral) 3. Signal transduction proteins (hormone reception, ...

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by keenangp
Thu Dec 18, 2008 4:54 am
 
Forum: Cell Biology
Topic: proteins found in the cell membrane.
Replies: 3
Views: 39925
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