Pericentric inversion


noun, plural: pericentric inversions

An inversion of a segment of chromosome in which the centromere is included, and breaks occur at both arms of the chromosome.


Chromosomal inversion happens when a segment of a chromosome breaks off and reinsert within itself. Inversions may not cause abnormalities in carriers as long as there is no extra or missing genetic information. However, individuals who are heterozygous for an inversion, there is a rise in the production of abnormal chromatids, especially when crossing-over occurs within the span of the inversion.

Word origin: Greek, from peri-: around, near + centric.
Compare: paracentric inversion.
See also: centric, inversion, chromosome.

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