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Perforin

perforin

(Science: protein) Perforins 1 and 2 form tubular transmembrane complexes (16nm diameter) at the sites of target cell lysis by natural killer cells and cytotoxic T-cells.


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Immune System

... as well make a list out of this! - Cell death can be due to phagocytosis or by the release of membrane perforating enzymes such as granzyme and perforin - both of these from NK or cytotoxic T-cells - that cause apoptosis. - Complement directly leads to the destruction of cells by causing a membrane ...

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by Babybel56
Tue May 10, 2011 7:05 pm
 
Forum: Human Biology
Topic: Immune System
Replies: 4
Views: 5056

Help with Immunology

... Thelper cells then stimulate both Tcytotoxic and Naive Bcells. T cytotoxic cells move to the site of inflammation by chemotaxis and either secrete perforin or differentiate into T suppresor cells. Stimulated Bcells either differentiate into plasma cells or memory b cells. Plasma cells secrete antibodies, ...

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by FoxintheBox
Tue Dec 18, 2007 11:45 pm
 
Forum: Physiology
Topic: Help with Immunology
Replies: 3
Views: 5852

Crazy question on Bio entrance exam

hey, you inveted for example a new complement system and a new way in which cytotoxic T-cells release their granzymes in a cell without perforin. :idea:

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by sdekivit
Sun Sep 17, 2006 8:23 pm
 
Forum: General Discussion
Topic: Crazy question on Bio entrance exam
Replies: 5
Views: 2063

How does your body get rid of viruses

... CD3, a marker of all lymphocytes. They play a role in non-specific cytoxicity, destroying pathogen-infected cells by releasing hydrolitic enzymes, perforin and granzyme. In a standard blood smear preparation they appear just like lymphocytes. You can distinguish them from lymphocytes by applying ...

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by Dr.Stein
Sat Jul 16, 2005 1:22 pm
 
Forum: Human Biology
Topic: How does your body get rid of viruses
Replies: 24
Views: 42350


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