Pepsinogen

Definition

noun, plural: pepsinogens

An inactive enzyme released by the parietal cells in the gastric pits of stomach.


Supplement

Pepsinogen is converted to pepsin by autocatalysis resulting in the cleaving of the excess amino acids in the presence of hydrochloric acid that creates an acidic gastric environment. Its release is mediated by the stimulatory action of the vagus nerve and gastrin when food is ingested.


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