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Pepsinogen

Definition

noun, plural: pepsinogens

An inactive enzyme released by the parietal cells in the gastric pits of stomach.


Supplement

Pepsinogen is converted to pepsin by autocatalysis resulting in the cleaving of the excess amino acids in the presence of hydrochloric acid that creates an acidic gastric environment. Its release is mediated by the stimulatory action of the vagus nerve and gastrin when food is ingested.


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Re: drink water, orange juice or Cola before eating?

... well as other enzymes (enzymes are all proteins but not all proteins are enzymes) such as trypsin start off with -ogen at the end of their name. Pepsinogen and trypsinogen. They are cleaved by the hydrochloric acid secreted by parietal cells in the stomach to pepsin and trypsin (both secreted ...

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by daniel.kurz
Mon Oct 24, 2011 12:26 am
 
Forum: Physiology
Topic: drink water, orange juice or Cola before eating?
Replies: 16
Views: 35760

Stomach bloating and weight gain

There is alpha-amylase and gastric lipase that is in the stomach. But you got me thinking about pepsinogen and how it needs a pH of 3.5 for optimal activity, and at least a pH of 5 for activation. Vegans are known to have a basic pH constitution, and I wonder if my stomach ...

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by kolean
Thu Jul 23, 2009 2:57 pm
 
Forum: Physiology
Topic: Stomach bloating and weight gain
Replies: 452
Views: 2683073

Re:

... fruits, and whole grains. While this might not help everybody, it appears to be at least helping me. Glad your open to input, aside from pepsinogen, most other digestive enzymes take place in the intestines, and any proteins that enter the stomach will most likely be broken down or denature. ...

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by MichaelXY
Thu Jul 23, 2009 8:29 am
 
Forum: Physiology
Topic: Stomach bloating and weight gain
Replies: 452
Views: 2683073

Re: Help! I am in a digestive crisis!

... Lactase - made in intestinal gland, functions in small intestine to break lactose to glucose and galactose Protein Enzymes Pepsin (secreted as pepsinogen) - made in gastric glands, functions in the stomach to break peptide bonds Trypsin (secreted as trypsinogen) - made in pancreas, functions ...

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by SOS
Tue Jun 23, 2009 8:21 pm
 
Forum: Physiology
Topic: Help! I am in a digestive crisis!
Replies: 2
Views: 7556

How would stomach react to water?

Stomach mainly produces gastric acid and pepsinogen. How would stomach react to water? Is gastric acid always present there in the stomach whether there is some food or not? If it is there all the time, then after the milk is drunk it would congest. ...

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by jackson6612
Wed Nov 07, 2007 6:45 pm
 
Forum: Human Biology
Topic: How would stomach react to water?
Replies: 0
Views: 887
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