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Dictionary » P » Pedigree

Pedigree

Definition

noun

(1) An ancestral line or chart depicting the lineage or descent of an individual.

(2) (genetics) A diagram showing the lineage or genealogy of an individual and all the direct ancestors, usually to analyze or follow the inheritance of trait.

adjective

(1) purebred.


Supplement

A pedigree can be used to determine the Mendelian inheritance of a genetic trait, especially familial diseases, across several generations of a family.


Word origin: From Anglo-French pe de gru, a variant of Old French pied de gru (“‘foot of a crane’”), from Latin pedem (“‘foot’”) + gruem (“‘crane’”).

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Pedigree Analysis

I want to know if I have this correct because I am confused. I think this is x-linked recessive is that right :?: since it can fall into this category 1.Usually more males than females are affected. 2. Affected sons are usually born to unaffected mothers; thus, the trait skips generations. 3. Approx...

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by chapsticks4
Tue Feb 26, 2013 7:06 pm
 
Forum: Genetics
Topic: Pedigree Analysis
Replies: 0
Views: 77

Re: Muscular dystrophy inheritance question

... a single-nucleotide polymorphism). This suggests the female may be a carrier with a DMD allele and a wild-type allele for dystrophin, but the pedigree makes it look like she is expressing the DMD phenotype. That confuses me; normally if a female has a DMD allele and a wild-type allele for ...

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by firefly
Wed Jan 09, 2013 9:16 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re: Muscular dystrophy inheritance question

... a single-nucleotide polymorphism). This suggests the female may be a carrier with a DMD allele and a wild-type allele for dystrophin, but the pedigree makes it look like she is expressing the DMD phenotype. That confuses me; normally if a female has a DMD allele and a wild-type allele for ...

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by jonmoulton
Wed Jan 09, 2013 5:06 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 1071

Re:

... not see it, so she seems like healthy, although she's not. That is the main problem. It's not sperm production as males are fertile according to pedigree. It's said to be a rare disease, so can you think of any male specific disease that autosomal? I sure cannot think of anything.

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by Cat
Tue Sep 11, 2012 2:39 pm
 
Forum: Genetics
Topic: Need help in an assignment
Replies: 17
Views: 5596

Need help in an assignment

Than I would say #3 based on information provided. The only male specific autosomal dominant condition I know about is male infertility. Judging by pedigree it's not that...

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by Cat
Sun Sep 09, 2012 5:58 pm
 
Forum: Genetics
Topic: Need help in an assignment
Replies: 17
Views: 5596
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