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Pdgf

PDGF --> platelet-derived growth factor

(Science: growth factor) The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing.

It is carried in the alpha-granules of platelets and is released when platelets adhere to traumatised tissues. Connective tissue cells near the traumatised region respond by initiating the process of replication.

The b chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for platelet derived growth factor, suggesting that transformation is caused by autocrine stimulation. The receptor is a tyrosine kinase.

Acronym: PDGF


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Fail to see under physiological stimulation

yes i am sure it was expressed and i also saw the activation of Src under PDGF stimulation detecting with pY416-Src antibody

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by kingsupercat
Wed Aug 28, 2013 4:34 am
 
Forum: Cell Biology
Topic: Fail to see under physiological stimulation
Replies: 6
Views: 1522

Fail to see under physiological stimulation

It's a single amino acid mutant Src that makes it always on. PDGF is one of growth factor that is known to activate endogenous Src. I had tried looking at both GFP-tagged exogenous or endogenous but all fail to see the phosphorylation of my protein evoked ...

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by kingsupercat
Mon Aug 26, 2013 2:37 am
 
Forum: Cell Biology
Topic: Fail to see under physiological stimulation
Replies: 6
Views: 1522

Fail to see under physiological stimulation

... Tyrosine in the presence of constitutively active Src mutant. However, I had been trying for an year to see if I could reproduce the result using PDGF to turn on endogenous Src activity and the results are all negative! Does anyone have good suggestion what to do next, or how to breakthru? thanks ...

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by kingsupercat
Wed Aug 21, 2013 2:48 am
 
Forum: Cell Biology
Topic: Fail to see under physiological stimulation
Replies: 6
Views: 1522

Please Help

... in retinoblastoma C-myc involved in Burkitt's lymphoma. Philadelphia chromosome in chronic myelogenous leukemia Platelet-derived growth factor (PDGF) C- ras involved in human bladder cancer

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by kpax
Tue Aug 25, 2009 2:33 pm
 
Forum: Genetics
Topic: Please Help
Replies: 2
Views: 7657

Mitosis multiple choice

... by Cdk c. the changing ratio of cytoplasm to genome d. its destruction by an enzyme phosphorylated by the cyclin-Cdk complex e. the binding of PDGF to receptors on the cell surface

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by wille2511
Fri Nov 16, 2007 2:37 am
 
Forum: Cell Biology
Topic: Mitosis multiple choice
Replies: 1
Views: 1831
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