Factor V deficiency

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A hemorrhagic disorder due to a deficiency of blood clotting factor V


Factor V deficiency is a condition characterized by a tendency to hemorrhage due to a deficiency of blood clotting factor V or proaccelerin. Factor V is a plasma glycoprotein that accelerates the conversion of prothrombin to thrombin in blood coagulation. It forms a complex (prothrombinase complex) with factor Xa, phospholipid, and calcium. The gene coding for factor V is located on the 1st chromosome, i.e. 1q23. Deficiency in factor V results in parahemophilia that manifests as mild to severe bleeding, epistaxis, bruising, menorrhagia, and hematoma.

Factor V deficiency is often associated with the disorder parahemophilia although the latter is also associate with venous thrombosis, which is blood clot occurring inside a vein, due to the mutant form of factor V (called Factor V Leiden). However, in factor V Leiden, the activity levels of factor V are normal despite the single point mutation in factor V gene.1

Factor V deficiency is also called Owren's disease. It is named after Paul Owren who identified and described it in Norway in 1943. It was also him who named the blood clotting factor component as factor V.

Factor V deficiency is a rare condition and is often hereditary although acquired condition may occur in certain individuals.


See also:

1 Kozyreva, O., May, S. K., and D'Silva, K. J. (5 October, 2016). Factor V Deficiency: pathophysiology. Medscape.com. Retrieved from [[1]].

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