Dictionary » O » Oncogenes


An oncogene is a modified gene, or a set of nucleotides that codes for a protein, that increases the malignancy of a tumor cell. Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer. New research indicates that small rnas 21-25 nucleotides in length called miRNAs can control expression of these genes by downregulating them.

The first oncogene was discovered in 1970 and was termed src (pronounced SARK). Src was in fact first discovered as an oncogene in a chicken retrovirus. Experiments performed by dr g. Steve martin of the university of California, Berkeley demonstrated that the src was indeed the oncogene of the virus. In 1976 Drs. J. Michael bishop and Harold E. Varmus of the university of California, San Francisco demonstrated that oncogenes were defective proto-oncogenes, found in many organisms including humans. For this discovery bishop and Varmus were awarded the Nobel Prize in 1989.

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... and EBNA3C (transcription regulators) that are responsible for transforming B cells into lymphoblastoid cells; in individuals with EBV, these oncogenes are upregulated resulting in repression of the pathways responsible for senescence like p16mk4A and pl4ARF (EBNA38-Deficent-Promotes-Cancer ...

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