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Oncogene

Oncogene

(Science: molecular biology, oncology) Mutated and/or overexpressed version of a normal gene of animal cells (the proto-oncogene) that in a dominant fashion can release the cell from normal restraints on growth and thus alone or in concert with other changes, convert a cell into a tumour cell. A gene that causes normal cells to change into cancerous tumor cells.A viral [[ Gene causing cancer induction.


An oncogene is a modified gene, or a set of nucleotides that codes for a protein, that increases the malignancy of a tumor cell. Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer. New research indicates that small rnas 21-25 nucleotides in length called miRNAs can control expression of these genes by downregulating them.

The first oncogene was discovered in 1970 and was termed src (pronounced SARK). Src was in fact first discovered as an oncogene in a chicken retrovirus. Experiments performed by dr g. Steve martin of the university of California, Berkeley demonstrated that the src was indeed the oncogene of the virus. In 1976 Drs. J. Michael bishop and Harold E. Varmus of the university of California, San Francisco demonstrated that oncogenes were defective proto-oncogenes, found in many organisms including humans. For this discovery bishop and Varmus were awarded the Nobel Prize in 1989.


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age and cumulative impact of carcinogens

... carcinogens never leave your system, so their damages accumulate more if they enter while you're young. Perhaps cancerous cells are more prone to oncogene activation because their cell division cycles have been messed up, or just because they divide more often, so an oncogene activated at a young ...

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by wildfunguy
Thu Aug 16, 2012 6:17 pm
 
Forum: Genetics
Topic: age and cumulative impact of carcinogens
Replies: 1
Views: 2974

Re: What are the potential benefits of epigenetics research?

... why people are researching it include: - loss of the modifications often leads to cancer (for example, failure to maintain suppression of an oncogene). - control of epigenetics is also how you reprogram cells to different functions, which is an important component of regenerative medicine. ...

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by AstraSequi
Wed Mar 28, 2012 7:25 pm
 
Forum: Evolution
Topic: What are the potential benefits of epigenetics research?
Replies: 4
Views: 6223

Re: Which came first the DNA, RNA or protein

... and other functions in most cells. B. Myc produces DNA binding protein http://www.answers.com/topic/myc-2 myc = Any of a group of vertebrate oncogenes whose product, a DNA binding protein, is thought to promote the growth of tumor cells. Possibly from my(elo)c(ytomatosis virus). C. From "How ...

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by Dov Henis
Mon Mar 22, 2010 9:23 pm
 
Forum: Molecular Biology
Topic: Which came first the DNA, RNA or protein
Replies: 64
Views: 53933

Difference between proto-oncogenes and tumor supressor genes

There is some overlap - a tumor suppressor could be a proto-oncogene. But not necessarily, and that's the focus of your question. Where do the terms not overlap?

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by Darby
Tue Mar 16, 2010 2:12 pm
 
Forum: Human Biology
Topic: Difference between proto-oncogenes and tumor supressor genes
Replies: 2
Views: 3303

Any experience of MEFS

Hello: Now I want to set up a serise of experiments as follows: 1.MEFs from Gene X KO mouse; 2.Lentivirus/Retrovirus of oncogene RAS infectionof MEFS; 3.Then the MEFS will be injected into nude mice; My questions are: 1.If MEFS can be infected by lentivirus/retrovirus; 2.If any experts ...

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by Chunshijia
Sat Jan 02, 2010 3:21 am
 
Forum: Cell Biology
Topic: Any experience of MEFS
Replies: 0
Views: 836
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