Dictionary » N » Notch



noun, plural: notches

(1) (anatomy) V-shaped cut, indentation, or nick, especially at the edge of an object or structure

(2) (developmental biology) A family of receptors, which upon binding with ligands, plays a major role in neurogenesis, specifically during lateral inhibition (wherein neuroblasts are singled-out from the neuroectoderm) and during binary cell fate specification (wherein ectodermal cells are prevented from differentiating into neuroblasts)


In developmental biology, the notch pertains to the a family of receptors (and the gene associated with their expression), which were first identified in fruit flies (Drosophila spp.). The name notch is derived from the notch that formed on the wings of fruit flies.

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Re: New to science (sort of), and need suggestions.

... tools. The magazine Scientific American is a good resource for undergrad-level reading outside of your field. American Scientist takes it up a notch, allowing a bit more math in the articles. To get really current stuff, try reading the editorial content of Nature or Science (don't worry about ...

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by jonmoulton
Fri Apr 27, 2012 3:20 pm
Forum: General Discussion
Topic: New to science (sort of), and need suggestions.
Replies: 3
Views: 2685

Can Genetic Variation Revert Back?

... it? I guess my question is: When is the point at which an adaptation becomes a change in the genetic code, thereby pushing the organism into a new notch of the evolutionary continuum?

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by PhillipusRex
Tue Jan 05, 2010 11:03 pm
Forum: Evolution
Topic: Can Genetic Variation Revert Back?
Replies: 14
Views: 11543

Re: Name a random science fact!

I don't know if it is true, but it would be awesome if it were A notch in a tree will remain the same distance from the ground as the tree grows. http://www.bio-one.org/wp/wp-content/uploads/2009/08/tree-grows-bike-small-300x237.jpg

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by dlambert
Wed Dec 09, 2009 4:30 pm
Forum: General Discussion
Topic: Name a random science fact!
Replies: 12
Views: 8208

Effect of DAPT on somite formation

... of somites formed. In the assessment, there is the question "Why should DAPT affect somite formation?". Now, I've read that DAPT blocks Notch signalling pathways, and that this pathway is important for the formation of the anterior-posterior identity of individual somites. But why do ...

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by Sannsibal
Tue Dec 01, 2009 7:00 pm
Forum: Molecular Biology
Topic: Effect of DAPT on somite formation
Replies: 0
Views: 2412

Religion Vs. Science

... at some other field. So, no you do not need to be an atheist in order to be a good scientist, but it seems to help, since big percentage of top notch scientists are atheists or agnostics when compared to people as a whole. Similarly, science and religion are not mutually exclusive, since in ...

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by biohazard
Tue Nov 03, 2009 7:52 am
Forum: General Discussion
Topic: Religion Vs. Science
Replies: 15
Views: 11502
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