Nonsense mutation

Definition

noun

A form of point mutation resulting in a nonsense codon that does not code for an amino acid and leads to a protein product that is early truncated.


Supplement


In nonsense mutations, the protein product from a sequence of DNA with a nonsense mutation is prematurely truncated, incomplete and often nonfunctional. Genetic disease such as Duchenne muscular dystrophy is caused by a nonsense mutation in gene responsible for a specific protein, for example, dystrophin.


Compare: missense mutation, silent mutation.
See also: point mutation


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