Nodes

... can already be seen - including increased susceptibility to infections. What comes to the immunological function, even more important are lymph nodes and the gut: without their proper function we would not survive.

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... I think i've got it now: The T cells are produced in the thymus as naive CD4+ and CD8+ cells and then recognise the antigen in the lymph nodes (mainly) but recently there have been RTE's discovered which are not yet CD4 or CD8 positive and differentiate upon activation

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... above), which determines e.g. the CD4+/CD8+ and A:B/G:D TCR development. The final adjustment, then, happens in the periphery (such as lymph nodes). Apparently RTEs are a relaively recent finding, with Haines et al. (2009) describing a protocol to indentify them, but for a good overall picture ...

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So after they have been activated in the lymph nodes they travel to the thymus where they differentiate and then migrate to infected tissue If anyone knows of a source which provides a good overview of this please let me know. I dont want to sound ...

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... sense!) but anyway here it is: Where does the differentiation of T cells take place? As i understand it when the t cell is activated in the lymph nodes it differentiates into Th and Tc. Tc go off to the inflamed tissue and Th cells diferentiate into Th1 and Th2 and the Th2 migrate to the B cell ...

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