nidogen --> entactin

(Science: protein) A dumbbell shaped 150 kD sulphated glycoprotein that is found in all basement membranes. It binds to laminin, forming a very stable 1:1 complex (KD = 10nM) and almost all laminin preparations contain entactin. The N terminal globular domain can self aggregate, whilst the C terminal globular domain binds to the short arm of laminin and to collagen iV. The connecting rod has 5-6 eGF type cysteine rich repeats, one of which has an RGD sequence for cellular interaction.

Please contribute to this project, if you have more information about this term feel free to edit this page

This page was last modified on 3 October 2005, at 21:16. This page has been accessed 5,768 times. 
What links here | Related changes | Permanent link