This occurs secondary to immaturity of liver cells (cannot effectively metabolise bilirubin) and the increased destruction of red blood cells (further releasing bilirubin into the bloodstream) that is normally seen in the newborn.
The jaundice usually appears between the 2nd and 5th days of life and usually clears by 2 weeks. Other factors which can potentiate jaundice in the newborn include: sepsis, biliary atresia, rhesus incompatibility, galactosaemia, cephalohaematoma, polycythaemia, g-6-P-D deficiency and congenital rubella, syphilis, toxoplasmosis or cytomegalovirus infection.
Results from our forum
... recently as 1946, erythroblastosis fetalis, or hemolytic disease of the newborn, affected between 0.5% and 1.0% of fetuses and newborns in the USA. ... in fetal organs; icterus gravis familiaris, a severe neonatal jaundice that often affected subsequent infants; and severe anemia in surviving ...
See entire post