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Neuroblastoma

neuroblastoma

(Science: oncology, tumour) malignant tumour derived from primitive ganglion cells. Mainly a tumour of childhood. Commonest sites are adrenal medulla and retroperitoneal tissue. The cells may partially differentiate into cells having the appearance of immature neurons.

The tumour shows a consistent deletion of the 1p36 region which is considered the site of the neuroblastoma I gene. Loss of the 1p36 region also correlates with amplification for the N-myc oncogene, particularly in later stages of the disease.

amplification of N-myc with dNA triploidy is associated with poor survival.

hereditary forms of the condition are rare and in such patients there is no risk for other cancers, which suggests a specificity of the antioncogene for neural tissues.


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help for neuroblastoma research

Hello every one. Can some warm-hearted person tell me how I can get gangalion tissue from wild type 129 mouse. we know neuroblastomas originated from mycn transgenic mouse often start from gangalion tissue in the abdomen. Cause this tissue is very tiny. I want to dissect this tissue for RT-PCR but I...

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by hp672001
Thu Jan 17, 2008 5:16 am
 
Forum: Cell Biology
Topic: help for neuroblastoma research
Replies: 0
Views: 941

The Fiber Disease

... readout, green fluorescent protein (GFP)-tagged mutant prion protein (PrP187R-GFP) and wild-type PrP (PrPC-GFP) were expressed in human neuroblastoma cells. We report that unlike PrPC-GFP that is expressed on the cell surface, PrP187R-GFP accumulates in the lysosomes of transfected cells. ...

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by J Jill
Sun Dec 10, 2006 4:48 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560385

I need your help!

You can go to the Nature.com where u may find the journal about the neuroblastoma cells

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by diponlove
Sat Nov 25, 2006 11:13 am
 
Forum: Cell Biology
Topic: I need your help!
Replies: 2
Views: 1139

I need your help!

I work with neuroblastoma cells and I'd like to know which is the maximum and minimum number of cells I can add in the toxicity assay. How I can truth the results? Do you know any article? Thank you very much

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by lsanchez
Fri Nov 24, 2006 10:28 am
 
Forum: Cell Biology
Topic: I need your help!
Replies: 2
Views: 1139

"Twenty questions"-biology game

Is it a neuroblastoma?

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by Micky T
Mon Sep 18, 2006 7:57 am
 
Forum: General Discussion
Topic: "Twenty questions"-biology game
Replies: 771
Views: 346125
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