Dictionary » N » Neuraminidase



(Science: enzyme) enzyme catalysing cleavage of neuraminic acid residues from oligosaccharide chains of glycoproteins and glycolipids.

Since these residues are usually terminal, neuraminidases are generally exo enzymes, although an endoneuraminidase is known.

For use as a laboratory reagent, common sources are from bacteria such as vibrio or clostridium. A neuraminidase is one of the transmembrane proteins of the envelope of influenza virus.

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Recombination in RNA viruses,Ruzic,Kovac

... with a synthetic RNA that contained the deleted region (Koetzner et al., 1992), and another with an in¯uenza A virus mutant with a damaged neuraminidase gene (Bergmann et al., 1992), recombination successfully repaired defective genes. Studies of recombination in bacteriophages, too, indicate ...

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by anakovacevic
Sat Jun 12, 2010 8:28 pm
Forum: Cell Biology
Topic: Recombination in RNA viruses,Ruzic,Kovac
Replies: 2
Views: 44142

The Fiber Disease

... characterization of an enterotoxin from extracts of E. histolytica. Infect Immun 48:211-218 Ifyeanyi AU, Leicht JG (1987) A membrane associated neuraminidase in Entamoaeba histolytica trophozoites. Infect Immun 55:181-186 Laemmli UK (1970) Cleavage of structural proteins during the assembly ...

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by Nadas Moksha
Sun Dec 10, 2006 3:16 am
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6246764

Prediction of mutations in H5N1 hemagglutinin

I think I've ever read in my virology book that influenza virus is truly can change its two protein markers which are hemaglutinin (H) and neuraminidase (N). And this changing process is done in two ways which are via genetic drift and via genetic shift whereas in genetic shift, the virus really ...

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by victor
Wed Nov 08, 2006 4:30 am
Forum: Human Biology
Topic: Prediction of mutations in H5N1 hemagglutinin
Replies: 1
Views: 1289

The Fiber Disease

... the surface, and with others (i.e. hemagglutinin (HA)) spaced widely apart. The major glycoprotein ( (HA) is interposed irregularly by clusters of neuraminidase (NA), with a ratio of HA to NA of about 4-5 to 1. Lipoprotein membranes enclose the nucleocapsids; nucleoproteins of different size classes ...

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by Skytroll
Fri Apr 28, 2006 8:02 pm
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6246764

Avian flu

... such as amantadine and rimantadine are now relatively useless because strains of the H5N1 virus have developed resistance to these drugs. Neuraminidase inhibitors such as zanamivir and oseltamivir (Tamiflu) are expensive. Tamiflu is in short supply, and many countries have insufficient ...

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by Inuyasha
Fri Dec 16, 2005 2:27 am
Forum: Microbiology
Topic: Avian flu
Replies: 47
Views: 19223
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