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Myosin

myosin

(Science: protein) A family of motor aTPases that interact with f actin filaments.

An increasing number of different myosins are being described. (See myosin light chains, meromyosin.) Myosin I is a low molecular weight (111-128 kD) form found in protozoa acanthamoeba and dictyostelium) that does not self assemble and is found in the cytoplasm as a globular monomeric molecule that can associate with membranes and transport membrane vesicles along microfilaments.

brush border Myosin I is a single headed myosin found in the microvilli of vertebrate intestinal epithelial cells, linking the membrane to the microfilament core. There is a single heavy chain of 119 kD and multiple (3 or 4) calmodulin light chains. The heavy chain has a C terminal domain that binds to acidic phospholipids.

Myosin II is the classical sarcomeric myosin that self assembles into bipolar thick filaments. Myosin II is a multimeric protein (440 kD) with two heavy chains (200 kD) and two pairs of light chains (17-22 kD) in each hexamer.

Between species and tissues there are considerable variations in the properties of Myosin II (see myosin light chains, meromyosin). Cytoplasmic myosin II is a family of sarcomeric myosin like proteins, also hexameric, responsible for force generation by interaction with microfilaments.

There are two heavy chains (up to 240 kD) and two pairs of light chains (15-20 kD), the self assembled filaments are shorter than those of the sarcomere. The MYO2 gene product is an unconventional myosin from yeast involved in polarized secretion. MYO2 may be similar to dilute myosin from mouse and p190 protein from vertebrate brain.

scallop myosin is directly calcium regulated (through regulatory and essential light chains) and is more similar to sarcomeric myosin than to the nonsarcomeric myosins. Smooth muscle myosin has two 200 kD heavy chains, two regulatory 20 kD light chains that can be phosphorylated, altering its binding to the heavy chains which induces a conformational change that renders the myosin active and two 17 kD light chains. The commonest protein in muscle; a globulin that combines with actin to form actomyosin.A [[protein found in muscle fibres that is involved in muscle contraction.


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myosin and actin constituent amino acids?

Do we know what the constituent amino acids of myosin and actin are, and the ratios of these amino acids in muscle tissue? Thank you.

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by mattw
Sat Aug 24, 2013 7:58 pm
 
Forum: Human Biology
Topic: myosin and actin constituent amino acids?
Replies: 1
Views: 717

Re: Yeast Mating Type Switching

... nuclei. Here it is shown thatASH1 messenger RNA (mRNA) preferentially accumulates in daughter cells by a process that is dependent on actin and myosin. A cis-acting element in the 3′-untranslated region of ASH1mRNA is sufficient to localize a chimeric RNA to daughter cells. These results suggest ...

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by fiona1985
Mon Aug 15, 2011 10:30 am
 
Forum: Cell Biology
Topic: Yeast Mating Type Switching
Replies: 3
Views: 6245

The skeletal muscle cell consists of?

The skeletal muscle cell consist of? im working on my final study guide and thats one of the questions. i was told the answer is actin and myosin but im not sure thats the right answer.

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by terestrife
Mon Apr 18, 2011 4:10 pm
 
Forum: Human Biology
Topic: The skeletal muscle cell consists of?
Replies: 1
Views: 1279

Re: Muscle Contractions

... muscle cell membrane (sarcolemma) which stimulates Ca2+ release from the sarcoplasmic reticulum to stimulate contraction (second messenger). The myosin fibers (on actin) are blocked by tropomyosin which is anchored by troponin. Ca2+ binds to troponin causing a conformational change thus moving ...

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by Jpoley
Tue Mar 01, 2011 2:42 am
 
Forum: Human Biology
Topic: Muscle Contractions
Replies: 1
Views: 6852

Muscle Contractions

... pages on these topics. I need to understand this process better for my Physiology class. I'm having a hard time understanding how actin and myosin react during a muscle contraction. The whole A band, I band, Z line thing is confusing me a bit. Thanks for your time.

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by raym1
Fri Feb 18, 2011 8:33 pm
 
Forum: Human Biology
Topic: Muscle Contractions
Replies: 1
Views: 6852
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