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Mx proteins

Mx proteins

GTPases (70-100 kD) found in interferon treated cells. Mx1 is found in the nucleus and determines the resistance of mice to influenza A virus by blocking transcription of the viral rNA genome. Other mx proteins are cytoplasmic and are related to dynamin.


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principle of error-prone PCR???

I've never heard about Mn in PCR (which doesn't mean it's not used) and to my knowledge they always provide magnesium, but there are proteins which work better with one or another (e.g. pyrophosphatase is specific for pyrophosphate with one metal while with the other it can cleave also other ...

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by JackBean
Tue Sep 30, 2014 8:19 am
 
Forum: Molecular Biology
Topic: principle of error-prone PCR???
Replies: 2
Views: 292

translation from DNA

... watchmaker trying to repair the watch by random changes and "seeing" (as he's blind) what works. It could be that in the RNA world the proteins were translated directly from the RNA (as nowadays) but when DNA started to work as information carrier, there would have to be too big changes ...

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by JackBean
Tue Sep 30, 2014 8:16 am
 
Forum: Molecular Biology
Topic: translation from DNA
Replies: 2
Views: 236

translation from DNA

why come proteins need RNA for translation. why cant they translate from DNA itself... All it needs is triplet of codons which can be provided by DNA too??

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by jannat
Sun Sep 28, 2014 6:27 am
 
Forum: Molecular Biology
Topic: translation from DNA
Replies: 2
Views: 236

Re: Any ideas for vaccine development or anti-viral drugs???

... antisense phosphorodiamidate morpholino oligomers (PMOs). A combination of EBOV-specific PMOs targeting sequences of viral mRNAs for the viral proteins (VPs) VP24, VP35, and RNA polymerase L protected rodents in both pre- and post-exposure therapeutic regimens. In a prophylactic proof-of-principal ...

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by jonmoulton
Mon Sep 15, 2014 3:04 pm
 
Forum: Cell Biology
Topic: Any ideas for vaccine development or anti-viral drugs???
Replies: 2
Views: 482

Re: Mitochondrial DNA

... size etc? As far as I know, no. mtDNA encodes some of the various components for the mitochondria such as the ETC (Electron Transport Chain) proteins such as ATP synthase and it's own ribosomal genes. Here is a pretty good representation of what mtDNA looks like. http://upload.wikimedia.org/wikipedia/commons/3/3e/Mitochondrial_DNA_en.svg

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by Zargo
Sun Sep 07, 2014 5:02 am
 
Forum: Genetics
Topic: Mitochondrial DNA
Replies: 2
Views: 694
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